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Study Detects Nattokinase Bioavailability in Human Serum

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By: Sean Moloughney

Editor, Nutraceuticals World

Scientists have been able to discern and document the bioavailability of nattokinase in human serum, according to a new study titled “Oral Bioavailability of Nattokinase (NSK-SD).”

Researchers, in conjunction with San Francisco General Hospital Department of Hematology, gave 11 healthy subjects aged 21 to 65 a single daily dose (2000 FU) in softgel capsules, providing 100 mg of purified nattokinase (NSK-SD), from Japan Bio Science Laboratory. Each volunteer was subject to blood draws at 0, 2, 4, 8, 12, 24 and 48 hours post ingestion of the supplement; blood draws were measured by ELISA using a rabbit polyclonal anti-nattokinase capture antibody.

The researchers observed a pharmacokinetic pattern for NSK-SO between baseline and 48 hours post-dose, peaking at approximately 13.3 hours (± 2.5 hours) post-dose. Statistically significant increases in detectable serum nattokinase from baseline were documented at time points t = 2 hours through t = 24 hours.

Nattokinase is a serine protease found naturally in natto, the traditional Japanese fermented soybean food. Nattokinase has been shown in a variety of studies to have significant profibrinolytic and antihypertensive effects, and is thus increasingly used as a supplement for the benefit of cardiovascular health.

For further information: www.jbsl-net.com/english

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